As I said in my previous review, this storyline continues where "Batman: Contagion" left off. To recap what has happened so far: The Clench has returned and it is fatal this time, Catwoman was forced to find an ancient wheel of plagues in the Sudan desert, Ra's Al Ghul and Bane are working together, and Batman is trying to stop a genocide.
This volume begins with how Bane met Ra's Al Ghul. Before the events of this story, Bane returned to Santa Prisca to learn who his father was, the man who condemned Bane to pay for his sins. He goes to ask a now old and blind Jesuit priest named Father Orestes, who used to visit the prisoners at Pena Duro. There are four possibilites to who Bane's father is/was: Sebastian/El Jeffe del Pais, a North American doctor, an English mercenary, or "The Swiss", who paid for the revolution. Despite the good rapport that seemed to exist between a younger Bane and the priest, as well as Father Orestes promising to keep all this encounter a secret ("as being under the seal of the confessional"), Bane still throws the old man out the window to his death, which is a very a-hole move in my opinion. Bane then continues to follow leads from one place to another, often killing the informant once he has the desired information. This is how Bane learns of the Order of Saint Dumas. While in Singapore, looking for information on "The Swiss", he runs into Talia, who is after a book called the Parthian. They fight, and she is impressed enough to take him with her to meet Ra's Al Ghul. Talia and her father agree that Bane would be a good tool for their mission, unaware that he can understand them. Bane is allowed to explore the library and, with the help of the librarian, discovers the secret to how Ra's Al Ghul is immortal: the Lazurus Pit. Despite Talia being repulsed, Bane has fallen in love with her (Ra's approved of their match for a time).
Catwoman (remember she was involved?) was captured by the League of Assassins and almost drowns but escapes (rescuing Umberto and Kai) and gets revenge on The Collector. Honestly, I'm not sure why she is included in this story. The reader could have learned about Eritrius and the wheel from a talk between Batman and Azrael.
Batman, Robin, and Nightwing learn that Ra's Al Ghul was the one behind the original virus and now he plan to release a worse strain (killing 90% of the world) in multiple cities: Paris, Edinburgh, Calcutta, and Gotham. Nightwing and Robin go to Paris while Batman heads to Edinburgh. The younger bats work with Henri Ducard to foil the League's plan at the Louvre, and Batman works with local Picts to stop the virus from spreading (and to return a stone; I don't know if this needed to be included either). In Calcutta, Batman meets Lady Shiva, and they work together to find the virus in a statue. With everyone back in Gotham, Batman blows up the newly built casino, destroying the virus with the fire and causing him and Bane to fight. Batman wins of course, but an unconscious Bane accidently drifts out to sea. Meanwhile, Nightwing, Huntress, and Robin focus on Ra's Al Ghul's ship, and Oracle tries to decode the diseases on the wheel. Ra's and Talia flee. The Batfamily might have saved the world, but there were still so many casulties... Alfred snaps Bruce and Tim out of their guilty mopping with the truth: you can't save everyone and if you didn't do what you could, more people would have died (including Tim himself).
After Bane drifted out to open water, he found and took over a large ship, a sort of nuclear powerplant. With only the original first mate left alive, Bane plans to pick up some League members and prove his worth to the Demon's Head (and Talia) by blowing up all of Gotham. They sail close to Bludhaven, where Nightwing is captured when he takes a look at the unathorized ship. Now in Gotham's port, Batman and Robin must save the day yet again. They can't let Bane succeed. In the end, Bane is defeated, the ship isn't going to sink enough to let the water touch the reactor core, and I am left to wonder how the reactor door will be shut without the person dying instantly from radiation.